Publications

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2022

Phelps GB, Amsterdam A, Hagen HR, García NZ, Lees JA. MITF deficiency and oncogenic GNAQ each promote proliferation programs in zebrafish melanocyte lineage cells. Pigment Cell & Melanoma Research. July 2022, 35, 539-547. doi: 10.1111/pcmr.13057/

Phelps GB, Hagen HR, Amsterdam A, Lees JA. MITF deficiency accelerates GNAQ-driven uveal melanoma. Proceedings of the National Academy of Sciences. May 2022, 119 (19). doi: 10.1073/pnas.2107006119

2021

Wilson M, Callens C, Le Gallo M, Mironov S, Ding Q, Salamagnon A, Chavarria TE, Viel R, Peasah AD, Bhutkar A, Martin S, Godey F, Tas P, Kang HS, Juin PP, Jetten AM, Visvader JE, Weinberg RA, Attanasio M, Prigent C, Lees JA and Guen VJ. An EMT-primary cilium-GLIS2 signaling axis regulates mammogenesis and claudin-low breast tumorigenesis. Science Advances. Oct 2021, 7 (44). doi: 10.1126/sciadv.abf6063

Mueller H, Fowler C, Dalin S, Moiso E, Udomlumleart T, Garg S, Hemann MT, Lees JA. Acquired resistance to PRMT5 inhibition induces concomitant collateral sensitivity to paclitaxel. Proceedings of the National Academy of Sciences. Aug 2021, 118 (34) e2024055118. doi: 10.1073/pnas.2024055118

Hazan R, Mori M, Danielian P, Guen VJ, Rubin SM, Cardoso WV, Lees JA.  E2F4's cytoplasmic role in multiciliogenesis is mediated via an N-terminal domain that binds two components of the centriole replication machinery, Deup1 and SAS6. Molecular Biology of the Cell. July 2021. doi: 10.1091/mbc.E21-01-0039

 

2020

Wilson MM, Weinberg RA, Lees JA, Guen VJ.  Emerging Mechanisms by which EMT Programs Control Stemness. Trends Cancer. 2020;S2405-8033(20)30120-5. doi:10.1016/j.trecan.2020.03.011  

 

2018

Parisi T, Balsamo M, Gertler F, Lees JA. The Rb tumor suppressor regulators epithelial cell migration and polarity. Mol Carcinog. 2018 Nov;57(11):1640-1650. doi: 10.1002/mc.22886. Epub 2018 Aug 26.

Perez DE, Henle AM, Amsterdam A, Hagen HR, Lees JA. (2018). Uveal Melanoma driver mutation in GNAQ/11 yield changes in melanocyte biology. Pigment Cell Melanoma Res. 2018 Mar 23. doi: 10.1111/pcmr.12700. [Epub ahead of print]

Guen, V. J., Edvardson, S., Fraenkel, N. D., Fattal‐Valevski, A., Jalas, C., Anteby, I., ... & Lees, J. A. (2018). A homozygous deleterious CDK10 mutation in a patient with agenesis of corpus callosum, retinopathy, and deafness. American Journal of Medical Genetics Part A, 176(1), 92-98.

 

2017

Braun CJ, Stanciu M, Boutz PL, Patterson JC, Calligaris D, Higuchi F, Neupane R, Fenoglio S, Cahill DP, Wakimoto H, Agar NYR, Yaffe MB, Sharp PA, Hemann MT, Lees JA. Coordinated splicing of regulatory detained introns within oncogenic transcripts creates an exploitable vulnerability in malignant glioma. Cancer Cell. 2017 Oct 9;32(4):411-426.e11. doi: 10.1016/j.ccell.2017.08.018. Epub 2017 Sep 28.

Mori M, Hazan R, Danielian P, Mahoney J, Li H, Lu J, Miller ES, Zhu X, Lees, JA, Cardoso W. (2017) Cytoplasmic E2f4 Forms Organizing Centers for Initiation of Centriole Amplification During Multiciliogenesis. Nat Commun. Jul 4;8:15857. doi: 10.1038/ncomms15857. PMID:28675157

Guen, V. J., Chavarria, T. E., Kröger, C., Ye, X., Weinberg, R. A., & Lees, J. A. (2017). EMT programs promote basal mammary stem cell and tumor-initiating cell stemness by inducing primary ciliogenesis and Hedgehog signaling. Proceedings of the National Academy of Sciences, 201711534.

Roper, J., Tammela, T., Cetinbas, N. M., Akkad, A., Roghanian, A., Rickelt, S., ... Lees, J…. Yilmaz, Omer. (2017). In vivo genome editing and organoid transplantation models of colorectal cancer and metastasis. Nature biotechnology, 35(6), 569.

Guen, V. J., Gamble, C., Lees, J. A., & Colas, P. (2017). The awakening of the CDK10/Cyclin M protein kinase. Oncotarget, 8(30), 50174.

 

2016

Ferretti R, Bhutkar A, McNamara MC, Lees JA. BMI1 induces an invasive signature in melanoma that promotes metastasis and chemoresistance. (2016) Genes and Development. 30(1):18-33 doi: 10.1101/gad.267757.115. Epub 2015 Dec 17 PMID: 26679841 PMCID: PMC4701976

Danielian, P. S., Hess, R. A., & Lees, J. A. (2016). E2f4 and E2f5 are essential for the development of the male reproductive system. Cell Cycle, 15(2), 250-260.

Guen, V. J., Gamble, C., Perez, D. E., Bourassa, S., Zappel, H., Gärtner, J., Lees J.A., and Colas, P. (2016). STAR syndrome-associated CDK10/Cyclin M regulates actin network architecture and ciliogenesis. Cell Cycle, 15(5), 678-688.

 

2015

Nicolay BN, Danielian PS, Lapek Jr JD, Kottakis F, Dehnad M, Gierut JJ, Tschöp K, Sanidas I, Manning AL, Morris R, Ramaswamy S, Haigis K, Bardeesy N, Lees JA, Haas W, Dyson NJ. (2015) Proteomic analysis of pRb loss highlights a signature of decreased mitochondrial oxidative phosphorylation. Genes and Development. Sep 1;29(17):1875-89. PMCID: PMC4573859

Parisi T, Bronson RT, Lees JA. (2015) Inactivation of the retinoblastoma gene yields a mouse model of malignant colorectal cancer. Oncogene. Nov 26;34(48):5890-9. doi: 10.1038/onc.2015.30. Epub 2015 Mar 9. PMCID: PMC4668801.

McFaline-Figueroa, J. L., Braun, C. J., Stanciu, M., Nagel, Z. D., Mazzucato, P., Sangaraju, D., ... Lees, J. A. …& Tretyakova, N. (2015). Minor changes in expression of the mismatch repair protein MSH2 exert a major impact on glioblastoma response to temozolomide. Cancer research.

Percival, S. M., Thomas, H. R., Amsterdam, A., Carroll, A. J., Lees, J. A., Yost, H. J., & Parant, J. M. (2015). Variations in sister chromatid cohesion dysfunction in esco2 mutant zebrafish reflects the phenotypic diversity of Roberts Syndrome. Disease models & mechanisms, dmm-019059.

 

Selected older publications

Maynard MA, Ferretti R, Hilgendorf KI, Perret C, Whyte P, Lees JA. (2014) Bmi1 is required for tumorigenesis in a mouse model of intestinal cancer. Oncogene. doi: 10.1038/onc.2013.333. PMCID: PMC3931743

Hilgendorf KI, Leshchiner ES, Nedelcu S, Maynard MA, Calo E, Ianari A, Walensky LD, Lees JA. (2013) The retinoblastoma protein induces apoptosis directly at the mitochondria. Genes and Development. 1:27(9):1003-15. PMCID: PMC3656319

Zhang G, Hoersch S, Amsterdam A, Whittaker CA, Beert E, Catchen JM, Farrington S, Postlethwait JH, Legius E, Hopkins N, Lees JA. (2013) Comparative Oncogenomic Analysis of Copy Number Alterations in Human and Zebrafish Tumors Enables Cancer Driver Discovery. PLoS Genet. Aug;9(8):e1003734. PMCID: PMC375708

Itzkovitz S, Lyubimova A, Blat I, Maynard M, van Es J, Lees JA, Jacks T, Clevers H, van Oudenaarden A. (2011) Single molecule transcript counting of stem cell markers in the mouse intestine. Nature Cell Biology. Nov 27;14(1):106-14. PMCID: PMC3292866

Calo E, Quintero-Estades JA, Danielian PS, Nedelcu S, Berman SD, Lees JA. (2010). Rb regulates fate choice and lineage commitment in vivo. Nature. 2010 466(7310):1110-4. PMCID: PMC2933655

Sansam CL, Cruz N, Danielian PS, Amsterdam A, Lau M, Hopkins N, Lees JA. (2010) A vertebrate gene, ticrr, is an essential checkpoint and replication regulator. Genes and Dev. 24:183-94. PMCID: PMC2807353

Parisi T, Bronson RT, and Lees JA. (2009). Inhibition of pituitary tumors in Rb mutant chimeras through E2f4 loss reveals a key suppressive role for the pRB/E2F pathway in urothelium and ganglionic carcinogenesis. Oncogene. 28(4):500-8. PMCID: PMC2633419

Dovey JS, Zacharek, SJ, Kim CF, and Lees JA. (2008) Bmi1 is critical for lung tumorigenesis and bronchioalveolar stem cell expansion. Proc. Natl. Acad. Sci. 105(33):11857-62. PMC2575250

MacInnes A, Amsterdam A, Hopkins N. and Lees JA. (2008) Loss of p53 protein in zebrafish tumors with ribosomal protein gene mutations. Proc. Natl. Acad. Sci. 105(30):10408-13. PMC2492501

Reinhardt, H. C., Aslanian, A. S., Lees, J. A., & Yaffe, M. B. (2007). p53-deficient cells rely on ATM-and ATR-mediated checkpoint signaling through the p38MAPK/MK2 pathway for survival after DNA damage. Cancer cell, 11(2), 175-189.

Iaquinta, P. J., & Lees, J. A. (2007). Life and death decisions by the E2F transcription factors. Current opinion in cell biology, 19(6), 649-657.

Aslanian A, Iaquinta PJ, Verona R, Lees JA. (2004) Repression of the Arf tumor suppressor by E2F3 is required for normal cell cycle kinetics. Genes Dev. 18(12): 1413-1422. PMCID: PMC423192

Amsterdam A, Sadler KC, Lai K, Farrington S, Bronson RT, Lees JA and Hopkins N. (2004) Many ribosomal protein genes are cancer genes in zebrafish. PLoS Biol. 2(5):690-98. PMC406397

Lee EY, Cam H, Ziebold U, Rayman JB, Lees JA, Dynlacht DB. (2002) E2F4 loss suppresses tumorigenesis in Rb mutant mice. Cancer Cell. 2(6): 463-472.

Fajas, L., Landsberg, R. L., Huss-Garcia, Y., Sardet, C., Lees, J. A., & Auwerx, J. (2002). E2Fs regulate adipocyte differentiation. Developmental cell, 3(1), 39-49.

Trimarchi, J. M., Fairchild, B., Wen, J., & Lees, J. A. (2001). The E2F6 transcription factor is a component of the mammalian Bmi1-containing polycomb complex. Proceedings of the National Academy of Sciences, 98(4), 1519-1524.

Humbert PO, Rogers C, Ganiatsas S, Landsberg RL, Trimarchi JM, Dandapani S, Brugnara C, Erdman S, Schrenzel M, Bronson RT, Lees JA. (2000) E2F4 is essential for normal erythrocyte maturation and neonatal viability. Mol Cell. 6(2): 281-291.

Brugarolas, J., Moberg, K., Boyd, S. D., Taya, Y., Jacks, T., & Lees, J. A. (1999). Inhibition of cyclin-dependent kinase 2 by p21 is necessary for retinoblastoma protein-mediated G1 arrest after γ-irradiation. Proceedings of the National Academy of Sciences, 96(3), 1002-1007.

Trimarchi JM, Fairchild B, Verona R, Moberg K, Andon N, and Lees JA. (1998) E2F-6, a member of the E2F family that can behave as a transcriptional repressor. Proc. Natl. Acad. Sci. 95 (6): 2850-2855. PMC19658

Moberg K, Starz M, and Lees JA. (1996) E2F-4 switches from p130 to p107 and pRB in response to cell cycle re-entry. Mol. Cell Biol. 16 (4): 1436-1449. PMC231128

Wu, C. L., Zukerberg, L. R., Ngwu, C., Harlow, E., & Lees, J. A. (1995). In vivo association of E2F and DP family proteins. Molecular and cellular biology, 15(5), 2536-2546.

Lees JA, Saito M, Vidal M, Valentine M, Look T, Harlow E, Dyson N and Helin K. (1993) The retinoblastoma protein binds to a family of E2F transcription factors. Mol. Cell Biol. 13: 7813-7825. PMC364853

Helin K, Lees JA, Vidal M, Dyson N, Harlow E and Fattaey A. (1992) A cDNA encoding a pRB-binding protein with properties of the transcription factor E2F. Cell 70: 337-350.